Mesenteric fat—control site for bacterial translocation in colitis?
نویسندگان
چکیده
منابع مشابه
Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility.
Nitric oxide (NO) has been implicated in the arterial vasodilation and associated vascular hyporesponsiveness to vasoconstrictors observed in liver cirrhosis. Bacteria, potent activators of NO and TNF-alpha synthesis, are found in the mesenteric lymph nodes (MLNs) of ascitic cirrhotic rats. Here, we investigated the impact of bacterial translocation (BT) to MLNs on TNF-alpha production, vascula...
متن کاملBacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats.
In cirrhosis, arterial vasodilation and the associated hemodynamic disturbances are most prominent in the mesenteric circulation, and its severity has been linked to bacterial translocation (BT) and endotoxemia. Synthesis of nitric oxide (NO), the main vasodilator implicated, is dependent on the essential cofactor tetrahydrobiopterin (BH(4)). The key enzyme involved in BH(4) synthesis is GTP-cy...
متن کاملEffects of glucagon-like peptide-2 on bacterial translocation in rat models of colitis.
BACKGROUND/AIMS The aim of this trial was to study the role of glucagon-like peptide-2 in reducing bacterial translocation by virtue of its anti-inflammatory effects and ability to decrease intestinal permeability in rat models of inflammatory bowel diseases. On the basis of our results and those of other recent studies, we suggest a new treatment modality for colitis. To our knowledge, this is...
متن کاملThe effect of propolisis and mesalazine on bacterial translocation in an experimental colitis model.
We read with great interest the recent brief communication by Aslan et al1 on the effect of propolisis and mesalazine on bacterial translocation in an experimental colitis model. We would like to thank the authors for all their efforts and valuable contribution. The paper adds to the current knowledge on the effects of propolis, however, it is rather confusing when they mentioned, a possibly re...
متن کاملIdiopathic Mesenteric Phlebosclerotic Colitis: A Case Report
Received: March 3, 2010 Accepted for publication: September 2, 2010 From the Department of Family Medicine, Department of Gastroenterology, Department of Colorectal Surgery Department of Pathology, Department of Emergency Medicine, Mackay Memorial Hospital, Hsinchu, Taiwan Address reprint requests and correspondence: Dr. Po-Chuan Wang Department of Gastroenterology, Mackay Memorial Hospital, Hs...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2012
ISSN: 1933-0219,1935-3456
DOI: 10.1038/mi.2012.33